Biomolecules

Profilbild Winter
Faculty of Life Sciences
Department of Biology

Cognitive Neurobiology

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Expertise

Prof. Winter’s research is focused on animal behaviour, especially cognitive performance, e.g. learning ability, memory and their neurobiological foundation for foraging. He carries out behavioural assessments for mice and rats, mostly for preclinical research, to investigate decision-making processes in animals. Lab space is available, inter alia at the Berlin Mouse Clinic for Neurology and Psychiatry (BMC), one of the leading diagnostic institutions within the NeuroCure Cluster of Excellence. Prof. Winter and his team also advise on experimental design and develop automated equipment and systems for behavioural studies on rodents for external laboratories. Another area of his expertise is virtual reality for humans. Here Prof. Winter focuses on the development of a compact, mobile, and immersive virtual reality environment for a wide range of uses.

Scientific Services

Behavioural analysis:

  • Computer controlled sensor and actuator systems for manipulation and measuring of behaviour
  • Modular software system for automated measuring of behaviour
  • RFID technology

Virtual reality:

  • Immersive 3D-virtual reality system with closed monitoring (octagon)
  • Software for rapid implementation of specific VR-applications and interaction scenarios
Testimonials
  • Planning and development of a system for automated diagnostics of parameters for motor skills after clinical surgery for a large international pharmaceutical group. 24h recording and measurement as operator independent system.
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Profilbild Ulrichs
Faculty of Life Sciences
Albrecht Daniel Thaer-Institute of Agricultural and Horticultural Sciences

Department of Crop and Animal Sciences, Urban Ecophysiology of Plants

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Expertise

Prof. Ulrichs is an expert in the field of ecophysiology of plants with a special focus on plants in urban spaces. His team studies processes, which determine plant growth, e.g. stress exposure in an urban environment. The emphasis of his research lies on the analysis of the secondary metabolite balance (incl. its nutritional function), substance allocation, competition and plant-insect interaction. Prof. Ulrichs other major field of expertise is the quality assurance in food supply chains of horticultural products, especially for perishable foodstuffs like fruits and vegetables in temperate zones as well as in tropical/subtropical regions.

Scientific Services
  • molecular methods
  • in-vitro propagation
  • HPLC
  • GC/MS
  • electroantennogram studies
  • trace gas analysis using photoacoustic spectroscopy
Testimonials
  • German specialty chemicals group: development of nanostructured plant protection agents
  • H. Lorberg Baumschulerzeugnisse GmbH & Co. KG (tree nursery): selection of climate-tolerant boulevard trees (Alleebaum)
  • Bein GmbH: development of electrostatic application processes of nanostructured elements
  • Bayer Crop Science: biosensors to prove the existence of plant viruses
  • XEROFLOR: development of vegetation carriers to prevent soil erosion in the Alps
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Profilbild Schröder
Faculty of Mathematics and Natural Sciences
Department of Geography

Geography of Soils and Quarternary Morphology

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Expertise

Prof. Schröder’s and his team’s research is focused on the non-destructive method of x-ray powder diffractometry to identify and characterise minerals. Subsequently, the powder samples can be analysed by other methods. The method of x-ray powder diffractometry and its content is closely related to the field of mineralogy and crystallography. Therefore, the method is used in materials research and building materials science. The team is working towards an implementation of the method in continuing and adult education, teaching and learning approaches. Materials suitable for x-ray powder diffractometry: Building materials, concrete, mortar, cement, fine and heavy ceramics, rocks, ores, sediments, ash, dust, filter and combustion residues. Potential fields of applications are: Clay mineralogical investigations (soil science - agriculture), archaeometric investigations (ancient colours and paints, bronze patina and archaeological ceramics), identification of unknown crystalline substances (fingerprinting), identification of crystalline phases, qualitative and semi-quantitative analyses of mixtures, isomorphisms, polymorphisms, determination of amorphous and crystalline states as well as state of crystallisation and particle sizes. The analysis is conducted with powder on a matrix < 32 µm and with texture specimen on a matrix < 2 µm.

Scientific Services
  • diffractometer “XRD 3003 Theta/Theta” (by Seifert) with the copper anode, qualitative mineral analysis and semi-quantitative phase analysis using the Rietveld-method
  • full qualitative mineral analysis and semi-quantitative phase identification using the Rietveld method
  • spectrometer “iCAP 6000” (by Thermo Scientific)
  • multi-element analysis
  • element determination using the ICP-OES acc. to DIN 38406-22
  • determination of the ignition loss
  • measuring of the pH value, the carbonate level, determination of iron soluble in oxalate solution and water content acc. to DIN 19683-4 in the soil
  • determination of the exchange capacity of the soil and replaceable cations acc. to DIN 19684-8
  • determination the composition of grain sizes by sieving acc. to DIN 19683-1, preparation with pyrophosphate of soda acc. to DIN 19683-1 and by laser diffraction
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Profilbild Leser
Faculty of Mathematics and Natural Sciences
Department of Computer Science

Knowledge Management in Bioinformatics

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Expertise

The research of Prof. Leser and his group is focused on all aspects of management, integration and analysis of heterogeneous, large and distributed data sets including natural language texts (text-mining and information extraction). This encompasses subjects such as data warehouses and ETL, graph databases, deep web and semantic web, machine learning, similarity search, scientific workflows, statistical methods of data analysis as well as methods for assessing and securing data quality. The team of Professor Leser conducts research in a variety of interdisciplinary projects, especially with colleagues from the life sciences covering the range from basic molecular biology to Systems Medicine.

Scientific Services

Very good IT-facilities:

  • several state-of-the-art parallel computer cluster (20-80 CPUs, 1 TB main memory)
  • cluster with 60+ cores
  • 50TB+ storage
Testimonials
  • For an IT service provider: Consultancy  and prototype development in the field of master data standardisation and integration
  • For an IT-manufacturer: Development and valuation of algorithms for analysing data quality
  • For an international pharmaceutical company: Consultancy and development of text-mining-procedures in biomarker development
  • For a medium-sized biotech company: Joint system development (partly funded by the German Federal Ministry for Economic Affairs and Energy) in the field of human genotype changes evaluation
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Profilbild Grimm
Faculty of Life Sciences
Department of Biology

Plant Physiology

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Expertise

Prof. Grimm and his team mainly investigate the metabolic control of tetrapyrrole biosynthesis and photosynthesis. They also do research on the regulation of sucrose transport in plants. The plant science team is interested in studying the unique properties and functions of plant cells, such as intracellular communication between the nucleus and the two main plant organelles, plastids and mitochondria. Prof. Grimm’s group applies several experimental methods and techniques from the areas of biochemistry, genetics, molecular and cell biology in their research and in the training programs for students and young academics.

Scientific Services

The Plant Physiology group provides all necessary equipment and instrumentation for plant growth and molecular genetics, biochemical and physiological work:

  • S1 greenhouse
  • growth cabinets for Arabidopsis
  • radionuclide laboratory
  • HPLC equipped with diode array and fluorescence detector
  • FPLC
  • fluorescence spectrometer
  • microtiter plate reader (w/ fluorescence detection)
  • UV/Vis photometer • PAM-2000 fluorometer
  • LI-COR photosynthesis device
  • fluorescence microscope
  • ultracentrifuges and high speed centrifuges including rotors
  • clean benches
  • incubators for growth of genetically modified bacteria and yeast
  • several PCR machines, e.g. microplate readers and PCR light cycler
  • confocal laser scanning microscope (CLSM)
Testimonials
  • Oil mills: pigments in rapeseed oil
  • Food-producing corporation: postharvesting treatment and storage of leafy greens
  • Pharmaceutical group: vitamin synthesis and content in plants
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Profilbild Dobbek
Faculty of Life Sciences
Department of Biology

Structural Biology / Biochemistry

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Expertise

Prof. Dobbek analyses the biochemical principles of bacterial growth on substrates, i.e. carbon dioxide, carbon monoxide as well as aromatic compounds, which also are pollutants. The main focus lies on the functional and structural investigation of metalliferous enzymes that transform unreactive molecules in oxygen free conditions and thus enable bacteria to grow in a seemingly hostile environment. Developing new (biological) catalysts capable of energy-efficiently transforming carbon dioxide and monoxide is Prof. Dobbek’s goal. Moreover these catalysts are designed to generate new enzymes for the biological decomposition of substances damaging to humans and the environment.

Scientific Services
  • production of proteins under aerobic and anaerobic conditions (FPLC and HPLC procedures)
  • robotic protein crystallization under standard conditions and in oxygen free conditions (glovebox technique)
  • crystallographic structural analysis of proteins
  • general methods in the field of structural bioinformatics
  • methods to examine enzymatic processes, e.g. fast mixing methods (stopped-flow spectroscopy under aerobic and anaerobic conditions), analyses using HPLC, GC-MS, UV/Vis- and fluorescence spectroscopy, isothermal titration calorimetry under aerobic conditions
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